Rebinyn May Interfere With Tests for COVID-19-related Coagulation Problems, Novo Nordisk Says

Rebinyn May Interfere With Tests for COVID-19-related Coagulation Problems, Novo Nordisk Says
0
(0)

Novo Nordisk has issued a notice warning healthcare professionals that the hemophilia B treatment Rebinyn (nonacog beta pegol, or N9-GP) can interfere with some laboratory tests that measure blood coagulation.

Following reports that people with severe COVID-19 may develop a blood-clotting condition similar to disseminated intravascular coagulation, the company cautions that not all coagulation tests will be suitable to monitor this coronavirus complication in hemophilia patients on Rebinyn.

Genentech published a similar notice last month warning that the hemophilia A treatment Hemlibra (emicizumab) can also interfere with these tests.

Rebinyn, marketed as Refixia in the European Union, is a replacement therapy approved for on-demand control of bleeds in adults and children with hemophilia B. It provides a modified form of the factor IX clotting protein, which is missing or defective in these patients.

However, due to its mechanism of action, Rebinyn may interfere with some laboratory tests measuring blood coagulation, causing doctors to overestimate the therapy’s coagulation potential in certain circumstances.

These tests are used for monitoring hemophilia but also help diagnose and monitor other diseases that affect coagulation. One such example is disseminated intravascular coagulation, which sometimes develops in severe coronavirus infections, independently of hemophilia.

As such, if a patient is taking Rebinyn and becomes infected with the new coronavirus, these tests may not accurately detect COVID-19-associated coagulation problems.

In particular, the company says that coagulation problems associated with COVID-19 result in a rise in fibrinogen — which is converted into fibrin during coagulation — and in d-dimer (fibrin’s degradation product).

Patients are routinely treated with heparin, a medication used as an anticoagulant, and should be monitored for their levels of platelets, d-dimer, and fibrinogen, as well as for the overall speed at which blood clots, using the activated partial thromboplastin time (aPTT) and prothrombin time (PT) tests.

Rebinyn is “known to interact with the reagents used for the aPTT test causing either erroneous shortening or prolongation of clotting time,” depending on the reagents used, the company wrote in the statement.

The statement also includes a table with the assays most commonly used to manage people with COVID-19-associated coagulation diseases, with information about whether they are affected by Rebinyn and recommended alternatives.

“If a haemophilia B patient on Rebinyn requires treatment for COVID-19, we recommend to proactively inform the treating healthcare provider about their factor IX treatment and provide them with the below table for increased awareness of its impact on coagulation assays,” the company’s statement reads.

Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.
Total Posts: 46

José holds a PhD in Neuroscience from Universidade of Porto, in Portugal. He has also studied Biochemistry at Universidade do Porto and was a postdoctoral associate at Weill Cornell Medicine, in New York, and at The University of Western Ontario in London, Ontario, Canada. His work has ranged from the association of central cardiovascular and pain control to the neurobiological basis of hypertension, and the molecular pathways driving Alzheimer’s disease.

×
Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.
Latest Posts
  • Rebinyn
  • CRP, VEGF in hemophilia A
  • Hemlibra notice
  • MarzAA

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?