Hemophilia Treatments

Even though there is currently no cure for hemophilia there are different ways to treat the condition. These include prophylaxis or preventative treatment, and recombinant factor concentrates, used depending on the type and severity of the condition.

1. Prophylaxis – regular preventive treatment, is typically administered three times a week.

2. Extended half-life (EHL) factor concentrates – alternative to prophylaxis and only available for hemophilia A and B these can also be used as a preventive measure. EHL factor concentrates work for longer periods after being administered, which is what researchers call ‘increased half-life’.

New long-lasting treatments are being developed and approved by regulatory authorities worldwide. Research pipeline is centered around the three main approaches:

  • Fc fusion
  • PEGylation (polyethylene glycol conjugation)
  • Albumin fusion

Two new longer-lasting factor concentrates developed with an Fc fusion technology were just approved by the U.S. Food and Drug Administration (FDA). These are:

  • Alprolix (BIIB029) – for hemophilia B (approved in March 2014)
  • Eloctate (BIB031) – for hemophilia A (approved in June 2014)

Long-lasting factor concentrates being synthesized through PEGylation are:

  • Refixia (N9-GP) – for hemophilia B (likely to receive a U.S. license next year)
  • N8-G9 – for hemophilia A
  • BAX-385 – for hemophilia A
  • Jivi (BAY 94-9027) – for hemophilia A

Another long-lasting product developed using the albumin fusion technique is:


Last updated: Mar. 9, 2020


Hemophilia News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.