Efanesoctocog alfa, now Altuviiio, approved in US for hemophilia A
Note: This story was updated Feb. 24, 2023, to correct the secondary headline since there are several other recombinant factor…
Articles by Lindsey Shapiro, PhD
Hem A patients in France report high satisfaction with Hemlibra
Hemophilia A patients at a single center in France reported high rates of satisfaction with Hemlibra (emicizumab) after…
Certain immune system proteins found to drive FVIII inhibitors
Researchers have identified immune system proteins that might drive the development of inhibitors, or neutralizing antibodies, against factor VIII (FVIII)…
More FVIII Antibodies May Predict Outcomes in Acquired Hemophilia A
High levels of antibodies against clotting factor VIII (FVIII) were associated with a slower response to immunosuppressive treatments in a…
FVIIa Therapy GEN-0828 Shows Efficacy in Hem B Mouse Study
An investigational factor VIIa (FVIIa) therapy called GEN-0828 may be able to minimize blood loss and accelerate blood clotting at…
Hemgenix Gene Therapy’s Benefits Sustained for 2 Years in Phase 3 Trial
The positive safety and efficacy profile of Hemgenix (etranacogene dezaparvovec) — the first and only approved gene therapy for…
Study Probes How Immune Reactions to Replacement Therapy Can Happen
Changes in the cellular microenvironment could influence immune responses against factor VIII (FVIII) replacement therapy in people with…
Disease Burden Persists for Hem A Patients in Japan Despite Treatments
Despite the increasing use of preventive factor VIII (FVIII) replacement therapy, people living with hemophilia A in Japan still…
Heart Risk Higher in Less Active Adult Hemophilia Patients: Study
Adults with moderate-to-severe hemophilia engage in less physical activity and have reduced physical fitness relative to healthy adults, according…
Study to Trace Onset of Inhibitors in Babies With Severe Hemophilia A
The National Institutes of Health (NIH) is supporting a university’s research into the risk factors and underlying mechanisms involved in…