SerpinPC, an investigational treatment that Centessa Pharmaceuticals is developing for hemophilia, will advance to interventional Phase 2 clinical testing later this year. The studies will support Centessa’s registrational program for hemophilia B. Such a program involves clinical trials that ultimately will lead to the company seeking regulatory approval…

Despite preventive treatment, people with hemophilia A or B report lower quality of life, mainly due to poor joint health, a study in Sweden shows. No significant difference was found between these two patient groups, who report high frequency of pain, mobility problems, and mental health issues like anxiety…

Proteins from tardigrades — microscopic animals known for their ability to survive in extreme conditions — could be used to stabilize replacement therapies for hemophilia A, allowing treatments to be stored for longer periods of time without refrigeration, a proof-of-concept study shows. “Our work provides a proof of principle…

For children with severe hemophilia A who develop inhibitors — neutralizing antibodies that reduce the effectiveness of standard therapies — starting treatment to eliminate inhibitors earlier is associated with a higher chance of success, a recent study reports. The study, “Low-dose immune tolerance induction therapy in…

Trauma comes in all shapes and sizes. People often associate trauma with physical injuries, such as a horrific accident, amputation, or burn wound, but it can be caused by many other situations as well. For example, early childhood trauma can develop when kids grow up with an abusive parent. Trauma…

My wife and I stood around my son’s hospital bedside, waiting for the anesthetist to come in and prepare my boy for surgery. My son Julian required a port-a-cath due to how much medicine had to be infused into his system daily. He was about 1 year old…

I often put myself in uncomfortable situations, especially when the health and well-being of my sons are at risk. There was a time when my youngest son, Caeleb, 17, was in the hospital more than he was at home. During those years, dealing with his hemophilia and inhibitor became…

I love the smell of a freshly painted room. The roller soaks up the new color as it moves around in the pan, waiting to be rolled onto the wall in big, broad strokes. The walls must desperately need a fresh coat of paint to soak up the new color…

Hemophilia A patients at a single center in France reported high rates of satisfaction with Hemlibra (emicizumab) after a year of real-world use, a study has found. Patients reported improvements in health and life quality, as well as reductions in pain and bleeding with the therapy, but problems…

For the past few weeks, I’ve written about my youngest son’s hospitalization in Houston when he was 11 months old. In one of those columns, I shared about Caeleb’s complications from a bleeding episode because of his circumcision. Caeleb spent several weeks in the hospital and eventually had a…