Posts by: Joana Carvalho

Joana Carvalho

May 6, 2019

Gene Therapy AMT-180 Induces Blood-clotting Activity in Animal Models of Hemophilia A

News

A single dose of the experimental gene therapy AMT-180 promotes clinically meaningful blood-clotting activity, independent of factor VIII levels, in mouse and primate models of hemophilia A, a study shows. ... Read more

April 29, 2019April 29, 2019

Gene Therapy Seen to Produce FVIIa Levels Needed to Control Bleeding in Rat Study of Hemophilia A

News

A gene therapy-based factor VIIa (FVIIa) given as prophylactic, or preventative, treatment was seen to produce specific factor levels needed to reduce the frequency of spontaneous bleeding episodes in a ... Read more

April 24, 2019April 24, 2019

Doctors in Canada Propose List of Measures to Judge Success of Transition Programs for Teens

News

Doctors in Canada are proposing a set of measures to better judge outcomes and the success of programs helping teen-age hemophilia patients transition to adult care, especially for those with more ... Read more

April 17, 2019April 17, 2019

Blood Clots in Older People with Acquired Hemophilia and Other Serious Ills Can Be Prevented, Case Study Finds

News

Recognizing risk factors of thrombosis and carefully monitoring medication doses are crucial for minimizing thrombotic complications in older patients with acquired hemophilia and serious illnesses like cardiovascular disease, a report describing ... Read more

March 29, 2019March 29, 2019

Sclerostin Linked to Bone Issues, Disease Severity in Children With Hemophilia A, Study Says

News

The levels of sclerostin, a protein that regulates bone formation, may be linked to disease severity and reflect bone alterations in children with hemophilia A, a study suggests. The ... Read more

March 25, 2019March 25, 2019

Population-Based Pharmacokinetic Dosing May Benefit Hemophilia A Patients, Study Reports

News

A population-based pharmacokinetic approach for tailored treatment regimens of hemophilia A patients may contribute to an increase in treatment adherence and a decrease in annual bleeding episodes, a study shows. The ... Read more

March 11, 2019March 11, 2019

Erectile Dysfunction More Prevalent with Age in Men With Hemophilia, Study Says

News

Erectile dysfunction, more commonly known as male impotence, is associated with older age in men with hemophilia, especially those who smoked long term and have high blood pressure, a study ... Read more

March 1, 2019March 1, 2019

Scientists Combine CRISPR-Cas9, Adenovirus Gene Delivery to Restore Function of FIX in Mice

News

Scientists successfully combined the gene-editing tool CRISPR-Cas9 and a special type of virus to deliver corrected genes to restore the function of the coagulation factor IX (FIX) gene in ... Read more

February 4, 2019February 4, 2019

Research into Physiotherapy and Rehab for Hemophilia Patients Needed, Review Says

News

People with hemophilia may benefit from physiotherapy and rehabilitation programs intended to manage bleeding and joint disease (arthropathy), but more research is needed to better understand those programs — and ... Read more

February 1, 2019February 1, 2019

Study Finds No Differences in Oral Health Quality of Life in Children With Hemophilia

News

Despite having lower oral health scores, children with hemophilia showed no differences in oral health-related quality of life compared to children without the condition, a study found. The study, “Parent’s report ... Read more

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