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Hemophilia is a blood disorder caused by a shortage of clotting factors, with no known cure, but various treatments exist to manage symptoms and improve life expectancy. Primary treatments include clotting factor replacement therapy, bypassing agents, gene therapies, and nonfactor replacement therapies. Experimental treatments and physiotherapy are also used to manage the condition.
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Hemophilia is classified as mild, moderate, or severe, depending on the level of clotting factor in the blood. About 70% of those with hemophilia have the severe form. The most important life-threatening complications of the disease are bleeding in the skull and hemorrhages in soft tissue around airways or other…