COVID-19 vaccines, because they work to stimulate the immune system, may be an emerging cause of autoimmune conditions like acquired hemophilia A, according to a case report. “This report aims to highlight the risk of … [acquired hemophilia A] following an immune stimulus, thus improving our knowledge regarding possible…
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A significant proportion of bleeds in people with hemophilia A are left untreated, according to an analysis of data from an observational study. Because only treated bleeds are typically reported in clinical trials, these findings suggested the full disease burden is not adequately captured in many studies. As such,…
Men with moderate-to-severe hemophilia A are again being enrolled in the Phase 3 AFFINE trial, which is testing the safety and effectiveness of SB-525 (giroctocogene fitelparvovec), an experimental gene therapy being developed by Pfizer and Sangamo Therapeutics. Pfizer, the study’s sponsor, had placed a voluntary pause…
Treatment with marstacimab (PF-06741086), an experimental antibody-based therapy developed by Pfizer, reduced the number of bleeds in patients with severe hemophilia who took part in a Phase 1b/2 clinical study. This held true regardless of whether patients had hemophilia A or hemophilia B, or had inhibitors…
Columnist Joe MacDonald was initially upset that his son required a cane at a marching band competition. Then he realized something important.
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