An enzyme called activate protein C (APC), which prevents the formation of blood clots and therefore promotes bleeding could be targeted to treat hemophilia, suggests a study conducted by researcher at the University of Cambridge and the Children’s Hospital of Philadelphia.
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Hemophilia A is a bleeding disorder caused by a deficiency in clotting factor VIII, affecting approximately 1 in 5,000 male births and accounting for about 80% of all hemophilia cases. Research is exploring new treatments, including engineered proteins that target activated protein C (APC) to prolong thrombin production, and gene therapies. COVID-19 has also been linked to acquired hemophilia A in some cases.
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While hemophilia A and hemophilia B are both bleeding disorders characterized by deficiencies in blood clotting factors, there are differences in one type versus the other, particularly in the specific genetic mutations that cause the disease, and in some of the treatment methods.
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